Plesio is a comune in the Province of Como in the Italian region Lombardy, located about 70 kilometres north of Milan and about 30 kilometres n…Plesio is a comune in the Province of Como in the Italian region Lombardy, located about 70 kilometres north of Milan and about 30 kilometres northeast of Como. As of 31 December 2004, it had a population of 833 and an area of 17.0 square kilometres.