Xenia is a village in Clay County, Illinois, United States. The population was 380 at the 2020 census. Xenia is located in southwestern Clay County at 38°38′15″N 88°38′15″W / 38.63750°N 88.63750°W. U.S. Route 50 passes to the north of the village, leading east 9 miles to Flora and west 17 miles to Salem.
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