Wythe County is a county located in the southwestern part of the U.S. state of Virginia. As of the 2020 United States census, the population was 28,290. Its county seat is Wytheville. Wythe County was formed from Montgomery County in 1790. It was named after George Wythe, the first Virginian signer of the Declaration of Independence. During the Civil …Wythe County is a county located in the southwestern part of the U.S. state of Virginia. As of the 2020 United States census, the population was 28,290. Its county seat is Wytheville. Wythe County was formed from Montgomery County in 1790. It was named after George Wythe, the first Virginian signer of the Declaration of Independence. During the Civil War the Battle of Cove Mountain was fought in the county.
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