Alzheimer’s disease, a devastating neurodegenerative disorder, is closely linked to the accumulation of tau protein in the brain. When tau becomes hyperphosphorylated, it forms neurofibrillary tangles ...
Excess DYRK1A activity has been shown to dysregulate tau splicing to favor the 3R isoform (Yin et al., 2017). In Down's syndrome, DYRK1A is overexpressed due to the presence of the gene in the trisomy ...
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