RNA repair enzymes capable of sealing 2’,3’-cyclic-PO 4 /5’-OH breaks or 3’-OH/5’-PO 4 breaks are present in diverse taxa in all phylogenetic domains of life. ATP-dependent RNA ligases join 3’-OH and ...

Enzymes called RNA polymerases transcribe DNA into RNA. RNA is the intermediary that carries the information contained within DNA to the ribosomes, where the genetic information is synthesized into ...

ATP (adenosine triphosphate) is the energy-carrying molecule used in cells because it can release energy very quickly. Energy is released from ATP when the end phosphate is removed. Once ATP has ...

In DNA, adenine pairs with thymine (T) through two hydrogen bonds, while in RNA, it pairs with uracil (U). Adenine is also a component of important biomolecules such as ATP (adenosine triphosphate), ...

The hydrolysis of ATP releases energy that is used to drive various cellular ... Several antiviral and anticancer drugs target the incorporation of adenine into DNA or RNA. For example, some ...

(2015) Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc. Natl. Acad. Sci. USA 112, 13868-13873. Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2017) Two-metal versus ...