Blaustein and colleagues concluded that activation of the PI 3-kinase signaling pathway by Ras(V12-C40) in turn activated AKT kinase, resulting in a change in the fibronectin splicing pattern to ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

Although inhibitors targeting elements of the PI3K/AKT/mTOR pathway are promising approaches ... 25 These findings provide strong rationale for testing mTOR kinase inhibitors such as MLN0128 ...

We have shown that inhibitors of PI3K, AKT, and mTOR all relieve feedback ... Our recent work has shown that Hsp90 is critical for oncogenic RAF kinase-driven ERK activation. The combination of Hsp90 ...