UMD researchers have discovered key mechanisms in gene regulation that could improve the design of RNA-based medicines.

UMD researchers uncover key mechanisms in gene regulation that may lead to better design of RNA-based medicines.

Although RNA is a single-stranded molecule, researchers soon discovered that it can form double-stranded structures, which are important to its function. In 1956, Alexander Rich—an X-ray ...

Multiple forms of double-stranded RNA (blue, magenta, orange structures) cross cell membranes with the help of a conserved protein located in novel sites (colored by depth) throughout the ...

as demonstrated by the recent successes of RNA vaccines and double-stranded RNA (dsRNA) therapies. But while health care providers can now successfully develop drugs that use dsRNA to accurately ...

Specifically, one strand of a double-stranded siRNA molecule can be incorporated into a complex called RISC. This RNA-containing complex can then inhibit transcription of an mRNA molecule that has ...

The system requires the use of Biosynthesis’s Blood RNA Preservative Tubes for blood collection and RNA stabilization, followed by RNA purification using spin column chromatography based on ...

Importantly, ManS was produced by a noncanonical biogenesis mechanism: The ribonuclease RNase III, which usually cuts double-stranded RNA, cleaves at a single-stranded region in the mRNA 3'UTR.

RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA ...