Complement in mammalian plasma recognizes pathogenic, immunogenic and apoptotic cell surfaces, promotes inflammatory responses and marks particles for cell lysis, phagocytosis and B-cell stimulation.

A component of the complement system promotes tumor growth by activating myeloid-derived suppressor cells. Figure 1: Multiple pro-inflammatory mediators in the tumor microenvironment increase the ...

To prevent bystander damage to host cells, complement is rapidly inactivated ... and thereby successfully shields itself from complement-mediated lysis. Read the full story here.

Daratumumab binds to CD38 and inhibits the growth of CD38 expressing tumor cells by inducing ... linking as well as by immune-mediated tumor cell lysis through complement dependent cytotoxicity ...