Dystrophin is an integral component of the dystrophin-glycoprotein complex (DGC), a large protein assembly that links the intracellular cytoskeleton of muscle fibers to the extracellular matrix.

These proteins form the dystrophin glycoprotein complex. Dystrophin and DGC are also lost in Duchenne muscular dystrophy. The loss of dystrophin and damage to the DGC appear to be key players in ...

At the other end (C-terminus), dystrophin interacts with β-dystroglycan, and the dystrophin-associated glycoprotein complex, which includes α-dystroglycan, the sarcoglycan subcomplex (α, β, γ,δ,and ε ...

We hypothesized that the syntrophins function as molecular anchors to link dystrophin and utrophin to other cell structures. To understand the organization of the utrophin complex at neuromuscular ...