In a pioneering collaboration with AbbVie, Northwestern researchers have discovered a new way to potentially treat cancer by ...
1). This mutation therefore ‘rewires’ the substrate specificity of an E3 ligase to induce aberrant degradation of proteins that are required for normal cellular function. Control of human ...
less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr. Yuan Liu from Indiana University will be joining Technology Networks to provide a ...
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Developing a simple, cost-effective method to identify the targets of a crucial protein-modifying enzymeThe diversity of cellular functions of ubiquitination is reflected in the existence of over 600 human E3 ligase genes, representing approximately 3% of the human genome. Mapping the human E3 ...
One early study revealed the kinetic basis for E3 ligase domains within the Nup358/RanBP2 nucleoporin, including structural characterization of a complex between human Nup358/RanBP2, the SUMO E2 Ubc9, ...
Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a linker acting as androgen ...
While the human genome encodes over 600 E3 ubiquitin ligases, TPD is currently limited to the few for which ligands have been reported, mostly CRBN and VHL. Identifying druggable E3 ligases that are ...
Increland has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an interleukin-1 receptor-associated kinase 4 (IRAK-4) ...
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