Estrogen is known to activate the ERK signaling pathway in a variety of different cell types. Figure 1: Mechanisms of rapid non-genomic receptor-dependent actions of estrogen in four cell types.

7 refine our understanding of the signaling effects of oncogenic KRAS. Rather than activating multiple effectors, mutant KRAS signals preferentially through the RAF–MEK–ERK pathway ...

The main goal of our laboratory is the identification and characterization of signal transduction pathways that ... that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR ...

The mechanistic (or mammalian) target of rapamycin (mTOR) signaling pathway, implicated in rapid ... with activation of the amygdala through ERK signaling. Further studies in a mouse model of ...

Researchers have identified a key pathway that links how neurons ... Zent et al, Synapse-to-nucleus ERK-CREB transcriptional signaling requires dendrite-to-soma Ca2+propagation mediated by L ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

and extracellular signal-regulated kinase (Erk) signaling pathways in ESCC cells, which enhanced the survival and migration of these cancer cells. Periostin also enhanced MSC and macrophage ...

Drug major Pfizer Inc. (PFE) announced Monday positive topline results from the progression-free survival or PFS analysis of the ...