Panel A summarizes the conventional model of how oncogenic RAS guanosine ... adenocarcinoma on ERK signaling. Together, these studies uncover novel compensatory pathways that may be involved ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

Spatiotemporal network dynamics govern cell fate decisions. We use the extracellular signal-regulated kinase (ERK) pathway as a paradigm to describe how temporal activation kinetics and spatial ...