When macrophages are actively fighting infections or responding to inflammation (as is the case with IBD), they activate a protein called hypoxia-inducible factor 1-alpha, or HIF-1α, to help them ...

Background Mechanical stress on the heart is commonly considered the sole stimulus explaining the synthesis and release of ...

As a result, this protein can bind to HIF1β and facilitate gene transcription of many HIF target genes (Figure 1; Schofield & Ratcliffe, 2004). Some organisms, like the roundworm C. elegans ...