Subtle signs of neurodegeneration can be detected in blood, CSF, and neuroimaging, up to 20 years before the motor symptoms ...

CAMBRIDGE, Massachusetts ‒ For decades it's been one of the defining mysteries of Huntington's disease. Why does the terrible devastation of mind and body start earlier in some people who ...

Scientists are unraveling the mystery of what triggers Huntington’s disease, a devastating and fatal hereditary disorder that strikes in the prime of life, causing nerve cells in parts of the ...

Scientists are unraveling the mystery of what triggers Huntington’s disease, a devastating hereditary disorder that strikes in the prime of life.

Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington's ...

This type of "somatic expansion" occurs in only the specific types of brain cells that later die in Huntington's disease. Only once a cell's DNA expansion reaches a threshold number of CAGs ...