Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National ...

New research has made a breakthrough in understanding how our cells manage to stay healthy by recycling important fat ...

The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...

Feng Wei at the Institute of Biophysics, Chinese Academy of Sciences, has made significant strides in understanding the BORC complex, a key player in lysosome transport and localization.

Breakthrough NUS discovery sheds light on cellular recycling mechanism and potential for treating rare diseases Singapore ...

During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases. Survival during fasting requires release of adipose tissue ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...

The autophagosome then fuses with another type of vesicle called a lysosome. The fused stage is called an autolysosome. The autolysosome ultimately matures into a lysosome, where the waste is ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...