MAPK pathway: uncontrolled growth via the MAPK pathway promotes melanoma cell growth.The pathway provides several sites for potential pharmacologic inhibition.RTK: Receptor tyrosine kinase.

The lab of The Wistar Institute's Jessie Villanueva, Ph.D., has identified a new strategy for attacking treatment-resistant ...

As part of The Wistar Institute's Melanoma Research Center, the Villanueva lab pursues new ways to overcome the challenge of melanoma drug resistance. In this paper, the group took aim at melanomas ...

The lab of The Wistar Institute's Jessie Villanueva, Ph.D., has identified a new strategy for attacking treatment-resistant melanoma: inhibiting the gene S6K2. .

Erasca is a biotech company focused on developing therapies for RAS/MAPK pathway-driven cancers with a strong financial ...

[31] Activation of this pathway results in the phosphorylation of MAPK, which then phosphorylates other factors and kinases, ultimately regulating cell survival, proliferation, and differentiation.

Researchers have discovered how a particular protein affects the growth and spread of colon cancer in humans. The study not ...

As part of The Wistar Institute’s Melanoma Research Center, the Villanueva lab pursues new ways to overcome the challenge of melanoma drug resistance. In this paper, the group took aim at melanomas ...