In this example, it activates an enzymatic cascade of MAP kinases. This results in potent ... activates an enzyme called a kinase. Learn how kinases initiate a signaling cascade that relays ...

However, the clinical efficacy of mitogen-activated protein kinase (MAPK) pathway inhibitors (MAPKi) for MAP2K1-mutant tumors is not well defined. We sought to characterize the genomic and clinical ...

We also show that there are differences in the signaling thresholds of the three mitogen-activated protein kinase (MAPK ... Grb2 expression and normal ERK activation in Grb2 +/− mice.