Autophagic death is attenuated by chemokines in circulation, surviving signaling and possibly other mechanisms ... support their mitogenic activity. Metastasis Formation by Disseminated Tumor ...

However, their role in the destruction of bone in melanoma metastasis remains unclear. Understanding the molecular mechanisms driving osteocyte death is crucial to developing effective treatments ...

The discovery of these shared genetic drivers—applicable to cancers from the lungs to the liver—challenges the long-held belief that metastasis mechanisms vary greatly between cancer types.

A team led by UT Southwestern scientists has discovered a mechanism that promotes metastasis in pancreatic, breast, and ...

Metastasis is an inefficient process. In vivo videomicroscopy and cell-fate analysis have led to the conclusion that early steps in metastasis are completed very efficiently. By contrast ...

This suppresses the Rho-GTPase-mediated mechanisms of metastasis. As a result, tumor cells can no longer migrate undisturbed and cannot attach themselves to other sites. Unlike many cancer drugs ...

But new research suggests an alternative mechanism has been overlooked—elusive mutations driving metastasis may not be developing within the twisted DNA of tumors themselves, but within the ...

Researchers have now uncovered a 'genetic signature' of 177 genes shared across multiple cancer types that drives this deadly process. Cancer metastasis -- the spread of cancer to other organs ...

This suppresses the Rho-GTPase-mediated mechanisms of metastasis. As a result, tumour cells can no longer migrate undisturbed and cannot attach themselves to other sites. Tumour cell is paralysed ...

work led by Dr. Massagué has identified genes and mechanisms that promote cancer metastasis to the bone, lung, and brain in a number of cancer types. This research has illuminated the basis for cancer ...

they are critical steps in the metastatic process that impose significant selective pressure on tumor cells. Therefore, the mechanisms employed during these early stages of metastasis are ...