Autophagic death is attenuated by chemokines in circulation, surviving signaling and possibly other mechanisms ... support their mitogenic activity. Metastasis Formation by Disseminated Tumor ...

A team led by UT Southwestern scientists has discovered a mechanism that promotes metastasis in pancreatic, breast, and ...

However, their role in the destruction of bone in melanoma metastasis remains unclear. Understanding the molecular mechanisms driving osteocyte death is crucial to developing effective treatments ...

The discovery of these shared genetic drivers—applicable to cancers from the lungs to the liver—challenges the long-held belief that metastasis mechanisms vary greatly between cancer types.

Metastasis returned when both ENPP1 and STING were inactivated ... “Through ENPP1, it is possible to leverage natural spatiotemporal control mechanisms for STING activation.” Wilson further opined ...

Metastasis is an inefficient process. In vivo videomicroscopy and cell-fate analysis have led to the conclusion that early steps in metastasis are completed very efficiently. By contrast ...

But new research suggests an alternative mechanism has been overlooked—elusive mutations driving metastasis may not be developing within the twisted DNA of tumors themselves, but within the ...

This suppresses the Rho-GTPase-mediated mechanisms of metastasis. As a result, tumor cells can no longer migrate undisturbed and cannot attach themselves to other sites. Unlike many cancer drugs ...

This suppresses the Rho-GTPase-mediated mechanisms of metastasis. As a result, tumour cells can no longer migrate undisturbed and cannot attach themselves to other sites. Tumour cell is paralysed ...

they are critical steps in the metastatic process that impose significant selective pressure on tumor cells. Therefore, the mechanisms employed during these early stages of metastasis are ...