The neuromuscular junction ... and characterize genes required for muscle formation, use, and maintenance. (See Figures 1, 2). We currently are generating human skeletal muscle from human pluripotent ...

We are interested in the biogenesis of skeletal muscle stem cells and understanding the failure of these cells to maintain the skeletal musculature in neuromuscular diseases. An additional interest is ...

Weak Voluntary Muscles: Skeletal Muscle Diseases, Neuromuscular Disorders ... at the neuromuscular junction, the space between a nerve cell and muscle fiber. Neuromuscular disorders can damage ...

skeletal muscle stem cells and gene therapy; growth factors and signal transduction; mouse molecular genetics; muscular dystrophies and neuromuscular diseases. Skeletal muscle maintenance and ...

The neuromuscular junction contains three types of nicotinic ... This open channel allows sodium and calcium ions to flow into the muscle cells and allows intracellular potassium to move outside ...

MF-300 target engagement inhibits 15-PGDH activity in biochemical assays, stabilizing and increasing levels of PGE2 in a cell ... of the neuromuscular junction, is reduced in skeletal muscle ...

Injecting cardiac stem cells might help ... 1 in 3,600 boys, is a neuromuscular disease caused by a shortage of a protein called dystrophin, leading to progressive muscle weakness.