Inhibitors K252a, PD98059, LY294002, and rapamycin (Calbiochem, Merck, Bad Soden, Germany), wortmannin (Cell Signaling, Danvers, MA, USA) and 1-butanol were used with concentrations indicated in ...

Glaucoma is a complex and multifactorial neurodegenerative disorder primarily characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons, leading to irreversible visual ...

and the common low-affinity p75 neurotrophin receptor as well as the activation of downstream PI3K/Akt and MAPK/ERK signaling pathways. However, their precursor proteins (pro-BDNF and pro-NGF ...