Deciphera Pharmaceuticals LLC has patented new serine/threonine-protein kinase B-raf (BRAF) and/or RAF proto-oncogene serine/threonine-protein kinase (RAF1; c-Raf) inhibitors reported to be useful for ...

The studies suggest that mutant KRAS signals predominantly through the rapidly accelerating fibrosarcoma (RAF ... related kinase (ERK). AF6 denotes afadin, GAP GTPase-activating protein, GEF ...

MAPK, mitogen-activated protein kinase; OS, overall survival ... Together, this demonstrates that oncogenic RAF1 mutants were found in RAF-dependent or RAF-regulated MAP2K1 mutants but not in ...

Well-characterized domains are Ras nanoclusters that may have a crucial control in input–output relationships in the Ras–Raf–MAPK/ERK kinase ... the gene or even protein level erodes.

MAP2K1 mutations have been functionally classified into three groups according to their dependency on upstream RAS/RAF signaling. However, the clinical efficacy of mitogen-activated protein kinase ...