This protein is one of the mammalian homologues of Sir2, known to extend lifespan in yeast and worms. SIRT1 then interacts with the coactivator PGC-1alpha, which, in turn, triggers glucose production, ...
Lagouge et al., "Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α," Cell, 127:1109-22, 2006. (Cited in 139 papers) The finding: In 2006 ...
This increased the activity of SIRT1, an NAD+-dependent deacetylase, enhancing the deacetylation and activity of PGC-1α.
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