The histone deacetylase Sir2 provides a seductive link between gene silencing and calorie restriction (CR), 1 but many debate the mechanism. Now researchers are turning to a new question: Does Sir2 ...
Sir2p, together with the nucleolar protein Net1p, forms part of a complex called RENT in the nucleolus 30, and this complex is distinct from that of the Sir2/3/4p complex. Loss of Net1p results in ...
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