What components constitute the translocation machinery (translocon)? How is it assembled and what are its structural characteristics? How are the substrates recognized and selected? What are the ...
The platform leverages state-of-the-art generative artificial intelligence (AI) to design selective inhibitors of the Sec61/translocon molecular complex for blocking and degrading disease-causing ...
triggers release of the nascent chain and its insertion into a protein conducting channel (‘translocon’). Besides challenging the prevailing view of signal sequence recognition, the new ...
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High-Resolution Structures Illuminate the Chloroplast Protein Import Machinery in PlantsThe translocon machineries, known as the TOC (translocon at the outer chloroplast membrane) and TIC (translocon at the inner chloroplast membrane) complexes, provide the route for preprotein ...
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