Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality. Targeting oncogenes and their interactive partners is an effective ...

The SNU BioTalk 2025 an International Conference, themed "Symphony of Cellular Signals in Metabolism and Immune Response," ...

For example, Notch signalling is active at very high levels in human t-cell lymphoblastic leukemia, Necakov says, and turning off the Notch pathway in this case, and in other types of cancer, “shuts ...

Excessive ROS can oxidize and damage cell proteins, lipids ... tissue damage and contributes to chronic disease. Inflammatory pathways like the nuclear factor-kappa B (NF-κB), cyclooxygenase ...