In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is commonly known to be responsible for protein trafficking and secretion. In ...

STING drives pro-inflammatory interferon cytokine production when double-stranded DNA is present in the cytosol, something that only happens in cancer cells. In 2013, a synthetic STING agonist, ...

However, when DNA is released into the cytosol, a condition that deviates from the norm, it indicates an underlying cellular ...