Medscape6d
Hepatic Fibrosis -- Role of Hepatic Stellate Cell Activation
Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...
Medscape6d
Hepatic Fibrosis -- Role of Hepatic Stellate Cell Activation
ECM can directly influence the function of surrounding cells through interaction with cell surface receptors, including integrins and nonintegrin matrix receptors (such as discoidin domain ...
eLife4d
R-Spondin Mimetic, SZN-043, Induced Proliferation and Wnt Activity, Two Features Deficient in Human Alcohol-Associated Liver Disease
This should be discussed. (7) Potential off-target effects of SZN-043, particularly in stellate cell activation in the context of fibrosis should be discussed. (8) Discuss the limitations of current ...
gut.bmj5d
Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension
az.vub.ac.be Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the ...
gut.bmj6d
Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors
jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...