In a pioneering collaboration with AbbVie, Northwestern researchers have discovered a new way to potentially treat cancer by ...

1). This mutation therefore ‘rewires’ the substrate specificity of an E3 ligase to induce aberrant degradation of proteins that are required for normal cellular function. Control of human ...

Alternatively, natural inhibitors of E3 ligases can be targeted to enhance their function ... Given the abundant presence of activated T-cells in human atherosclerotic lesions, modulation of T-cell ...

Vivek Vishnudas discusses the unique advantages of E2-based TPD and its potential to revolutionize treatment for challenging diseases.

and many poxvirus E3 ubiquitin ligase substrates remain to be explored. The homologies between genes from different poxviruses and between poxvirus genes and human genes have aided the rational ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

E3-ubiquitin ligase inducible degrader of the LDL receptor ... hypercholesterolemia Clinical Phase II study Amgen AMG145 is a human monoclonal IgG2 that binds specifically to PCSK9 Reduced LDL ...

Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a linker acting as androgen ...

Increland has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an interleukin-1 receptor-associated kinase 4 (IRAK-4) ...

Powered by a 9.2 kWh battery, it features three driving modes and TVS SmartXonnect™ technology for real-time navigation and diagnostics. TVS launches e3-wheeler, priced at Rs 2.95 lakh.

This study identifies 47,350 enhancers active in human neurons during differentiation and links some to genes involved in ...