High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...

High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...

Vitamin E succinate has been found to inhibit tumor growth and enhance the effectiveness of immunotherapy by targeting ...

During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other proteins. This tagging, in turn, helps determine the fate of the targeted ...

Merck Sharp & Dohme LLC patents report the development of proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase (Von Hippel-Lindau disease tumor suppressor [VHL] ligands) ...

These innovative compounds leverage the ubiquitin-proteasome system (UPS) to degrade challenging targets, providing new avenues for intervention beyond traditional small molecules. However, the power ...

a feature shared with many other ubiquitin and ubiqutin-like E3 ligases. Subsequent studies revealed a structural basis for the ZNF451 SUMO E3 ligase, and the structural basis for substrate ...

Through its E-rich motif, VGLL3 associates with KLHL15, an E3 ubiquitin ligase adapter, to prevent CtIP from proteasomal ...

In this study, we will establish the role of RING genes in fungal susceptibility using a RING gene knockout collection and Botrytis cinerea as model pathogen, through the high-throughput screening ...

Researchers at the University of Chicago Medicine identified vitamin E succinate (VES) as an effective agent in suppressing tumor growth by promoting FTO degradation. This enhances T-cell cytotoxicity ...