Vitamin E succinate has been found to inhibit tumor growth and enhance the effectiveness of immunotherapy by targeting ...
High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...
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Study identifies vitamin E succinate as key to tumor growth controlHigh levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...
Researchers at the University of Chicago Medicine identified vitamin E succinate (VES) as an effective agent in suppressing ...
Merck Sharp & Dohme LLC patents report the development of proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase (Von Hippel-Lindau disease tumor suppressor [VHL] ligands) ...
Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins. Based on their functional domains and ...
Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a linker acting as androgen ...
As an E3 ubiquitin ligase, it catalyzes the ubiquitination of various substrates, including adaptor proteins (MAVS and STING) and transcription factors (NF-κB and IRF3), thereby exerting positive or ...
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