High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...
Merck Sharp & Dohme LLC patents report the development of proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase (Von Hippel-Lindau disease tumor suppressor [VHL] ligands) ...
High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...
Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a linker acting as androgen ...
Nine U of A students, the largest group ever, shared their STEM research with elected officials, educators, peers and fellow presenting students from 13 Arkansas institutions.
This occurs through interactions with the protein FBXO31. On binding CTAPs, FBXO31 summons a ubiquitin ligase to tag the modified proteins for dismantling by the proteasome. Curiously, loss of FBXO31 ...
We determine the crystal structure of the C-terminal part of IFT172, uncovering a conserved U-box-like domain often found in E3 ubiquitin ligases. This domain exhibits ubiquitin-binding properties and ...
WWP1, a member of the C2-WW-HECT E3 ligase family, is an E3 ubiquitin-protein ligase containing WW domains. This enzyme plays a critical role in regulating diverse cellular processes. Its expression ...
When encountering cellular stress, E3 ligases must deal with proteins that have been damaged in many different ways. For example, misfolding can expose multiple hydrophobic regions in the same ...
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