Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.

Septerna has a market cap of $750mn and $130mn in cash and ST investments. Discover SEPN's groundbreaking drug discovery ...

In this section, signal-transduction proteins and pathways that convert the chemical stimulus to a cell into a positive or negative regenerative cellular response are listed.

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

The G protein-based signaling mechanisms underlying these effects were not thoroughly investigated in this study, however the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and ERK1/2/MAPK ...

Adewolu Abiodun, a PhD researcher at Texas Tech University, discusses his work in glycomics and proteomics, focusing on disease detection, precision medicine, and the role of plant-based compounds in ...

Graying hair is a hallmark of aging, often considered an inevitable part of growing older. However, recent research from ...

The oxytocin receptor (OXTR) is a G protein-coupled receptor with a diverse repertoire of intracellular signaling pathways, which are activated in response to binding oxytocin (OXT) and a similar ...

Although gut microbiota and lipid metabolites have been suggested to be closely associated with type 2 diabetes mellitus (T2DM), the interactions between gut microbiota, ...

In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and ...

Dry January is mostly pain and not so much gain, says our writer. It’s month two and three that you really start to enjoy the ...

A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...