eLife9d
Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice
(g and h) Relative renal genes for uric acid reabsorption expression in the indicated groups by qPCR (n = 6), including URAT1 (g) and GLUT9 (h). (i-k) Relative renal genes for uric acid excretion ...
Frontiers11d
Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP
Besides being a neuronal fuel, L-lactate is also a signal in the brain. Whether extracellular L-lactate affects brain metabolism, in particular astrocytes, abundant neuroglial cells, which produce ...
Frontiers18d
Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge
With the changes in modern life, hyperuricemia (HUA) has become a serious universal health issue, leading to rising morbidity and mortality. Characterized by elevated levels of UA, HUA has become an ...
BMJ12d
Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1
Objectives Human urate transporter 1 (URAT1) is a member of the organic anion transporter family (SLC22A12) that primarily regulates the renal tubular reabsorption of uric acid. This case–control ...