Symptoms of Huntington's disease appear late in life. Research reveals how DNA repeats grow toxic over time, explaining the ...

Subtle signs of neurodegeneration can be detected in blood, CSF, and neuroimaging, up to 20 years before the motor symptoms ...

New genetic research shows why some people develop deadly Huntington's disease earlier than others. The findings could lead to better treatments.

Huntington's disease kills a population of cells called ... Seeking to understand the direct biological effects of CAG-repeat length, the researchers adapted single-cell RNA-sequencing to help ...

Huntington's disease kills a population of cells called ... Seeking to understand the direct biological effects of CAG-repeat length, the researchers adapted single-cell RNA-sequencing to help ...

People genetically susceptible to Huntington's disease often see their movement ... This happens repeatedly until the CAG/CTG repeats expand enough to interfere with the function of the huntingtin ...

The findings, which could lead to new ways to prevent or treat the disease, have been reported in Cell. The mutations that cause Huntington's involve a repeat of a three base pair sequence: CAG in the ...

“A lot was known about Huntington’s disease before we started this work ... more rapidly in some neurons than others and how the CAG repeats over 150 repeats trigger cell death.

The number of CAG repeats in blood cells correlates with ... that blocking repeat expansion could delay the onset of Huntington’s disease.