Pharmaceutical ads are difficult to avoid in American television programming and a growing number of them promote a class of ...

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying ...

The study found that a particular signaling pathway, the JAK/STAT pathway, was highly active in patients with toxic epidermal necrolysis (TEN), the most severe skin reaction studied. This pathway ...

Altogether, they identified six proteins involved in the JAK/STAT pathway that are upregulated in those with the skin infection. The JAK/STAT pathway is the main driver of skin inflammation ...

Overall, the research indicates a growing understanding of the JAK/STAT signaling pathways involved in alopecia areata, which has led to the development of targeted therapies. The success of these ...

The macrophage polarization-related pathways involving STAT3 include: Janus kinases (JAK)/STAT signaling pathway, NF-κB signaling pathway, phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) ...

such as the IL-12/IL-23 pathway and the JAK/STAT pathway. Most of these new drugs are in advanced phases of study and have shown promising efficacy in patients with IBD. Although JAK-targeting small ...

Cannabigerol (CBG), a cannabis compound, may help to treat atopic dermatitis (AD), according to a study published in the journal Cells. Researchers from the Catholic University of Korea used both ...

JAK inhibitors (JAKi) can regulate JAK-STAT pathway and decrease the interferon-induced STAT1 phosphorylation, and has been applied into both adult DM and patients with JDM.2–5 Here, we share the ...

Janus-kinase and signal transducer and activator of transcription (JAK-STAT) signalling pathway is implicated in the pathogenesis of PsA. Objectives To examine the effect of tofacitinib (JAK inhibitor ...