A new study led by Dr. Rodrigo Maillard at Georgetown University, “Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein through Structural Homology,” published in ...
Mechanistically, STAT5 deletion induces the expression of the proliferative factors Cyp19a1/aromatase and IL-6, which enhance ER signaling in the mammary gland (Brady et al., 2017). It would be ...
However, the excessive accumulation of misfolded proteins recruit GRP78 away from all three ER stress sensors, leading to activation of downstream signal transduction pathways. Upon ER stress, PERK ...