In an exciting advancement for dermatological science, researchers have uncovered a potential role for vitamin D and the enzyme CYP24A1 in the development of keloid scars—an elusive and challenging ...

Keloids are fibrotic scars that extend beyond the boundaries of the original wound, often causing physical disfigurement and emotional distress.

Keloids are fibrotic scars that extend beyond the boundaries of the original wound, often causing physical disfigurement and emotional distress. These scars are driven by an overproduction of ...

Here we report an activity-dependent stabilization of the MAP kinase (MAPK) pathway, prominent in hippocampal dendrites. The longevity of the signal in these dendrites was increased to hours when ...

Certain people are prone to keloids, a type of raised scar caused by dysfunctional wound healing. Surgery is an option to get rid of them, but for those unable or unwilling to undergo such procedures, ...

By targeting CYP24A1, the study highlights a novel therapeutic pathway that could mitigate the fibrotic characteristics of keloids, offering a beacon of hope for improved treatment outcomes. Keloids ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Department of Neurosurgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 152 Aiguo Road, Nanchang, Jiangxi 330006, China Department of ...

Ritlecitinib is under clinical development by Pfizer and currently in Phase II for Keloids. According to GlobalData, Phase II drugs for Keloids does not have sufficient historical data to build an ...