Here the authors show that this decrease in IFN-I production and related pDC functions may be attributed to suppressed oxidative and glycolytic metabolism of pDCs, with lactate dehydrogenase B ...

In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...

Microplastics pose a threat to heart health, causing harmful changes in vascular cells and increasing the risk of ...

This Review outlines the molecular basis of DC maturation, highlights the mechanisms through which ... and glycolytic metabolism of pDCs, with lactate dehydrogenase B identified as a regulator.

Axatilimab was generally well tolerated, with a safety profile that was manageable and consistent with the mechanism of action of CSF-1R ... (11.4%), increased lipase (11.4%), increased lactate ...

Hexokinase 2 (HK2), phosphofructokinase-1/6 (PFK-1/PFKFB3), pyruvate kinase M2 (PKM2), pyruvate dehydrogenase kinase/pyruvate dehydrogenase (PDK/PDH), and lactate dehydrogenase A ... the progression ...

Lactate dehydrogenase decolourisation was not found in any of the ... The results in our study suggest, but as yet do not prove, the following hypothetical pathophysiological mechanism in patients ...

Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui 233030, China Clinical Testing and Diagnose Experimental Center, ...

China: A recent cross-sectional study conducted in Hefei, China, has identified serum lactate dehydrogenase (LDH) levels as a potential novel predictor for the severity of metabolic ...

The international team describes their results and the underlying molecular mechanism in Cell Metabolism. Ergothioneine is a natural compound found in certain fungi such as oyster or shiitake ...

"These findings illuminate a critical mechanism that connects local synaptic activity to the broader gene expression changes necessary for learning and memory," said Mark Dell'Acqua, professor of ...

The cause of secondary HLH can be multifactorial, often with a predominant underlying cause, but the pathophysiological mechanisms are still incompletely understood. According to the threshold ...