Here we show that activation of the lactate receptor HCAR1 in colorectal tumor cells leads to the recruitment of immunosuppressive PMN-MDSCs to tumors, thereby impairing anti-tumor immunity and ...

The temporal bone is part of the skull above the ear. One part of the temporal bone is called the mastoid bone. It is the lumpy bit you can feel behind your ear. The outside of the mastoid bone is a ...

When a child develops a brain tumor, early diagnosis is essential. Alan Cohen, M.D., director of pediatric neurosurgery at Johns Hopkins Children’s Center, shares the most common signs and symptoms ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

The tissue adjacent to a tumor behaves differently than areas farther away: The tumor’s cancerous cells influence their surroundings, blocking the body’s immune defenses and creating a sort of haven ...

Each child’s outlook can vary based on factors specific to them. The most important factors in determining a child’s outlook are the stage and histology of the tumor. (Histology refers to how the ...

The stage of a cancer describes how far it has spread. To a large extent, your child’s treatment and prognosis (outlook) will depend on the stage, histology, and risk group of their Wilms tumor.

Some forms of brain cancer can be life-threatening. Diagnosed with a malignant skull base tumor declared inoperable by other surgeons, Sofia, a Connecticut teenager, came to Johns Hopkins and had her ...