Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National ...

The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...

New research has made a breakthrough in understanding how our cells manage to stay healthy by recycling important fat ...

The protein Spns1 helps transport fat molecules out of lysosomes, preventing harmful buildup and offering insights for rare ...

During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases. Survival during fasting requires release of adipose tissue ...

The autophagosome then fuses with another type of vesicle called a lysosome. The fused stage is called an autolysosome. The autolysosome ultimately matures into a lysosome, where the waste is ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...

Breakthrough NUS discovery sheds light on cellular recycling mechanism and potential for treating rare diseases Singapore ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...