In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

Signaling via the MAPK pathway is important for proliferation ... We thank Santiago Cortés for help in preparation of the figures and illustrations and Anneliis Ihermann-Hella for providing the in ...

The following is a summary of “Anakinra improves retention rate of targeted treatments in Erdheim-Chester disease,” published ...

This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan Center for Life Sciences, ...

Hope is not passive wishing but an active, dynamic process. According to Hope Theory, hope involves two components: agency and pathways. Agency is the belief in one’s capability to act ...

Z526- a novel dithiocarbamate-like compound reverses cancer associated cachexia via mitigating NF-B signaling and oxidative ...

This discrepancy indicates that the etching procedure introduced extraneous conductive pathways unrelated to the VHE, thereby explaining why a reduced band gap had been observed in prior ...

A beloved illustrator died in the middle of a project. His son, who had been drifting away from art for years, was given the chance to finish the work. Credit... Supported by By Liz Moore Liz ...

We reviewed the best free Adobe Illustrator alternatives for managing graphics files without a Creative Cloud subscription. We've rounded-up our top-rated choices for when you want to make the ...