EurekAlert!14d
Schematic illustration of Z526's effects on cancer-associated cachexia. (IMAGE)
In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...
C&EN15d
Blocking the p38 MAPK Signaling Pathway in the Rat Hippocampus Alleviates the Depressive-like Behavior Induced by Spinal Cord Injury
Department of Neurosurgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 152 Aiguo Road, Nanchang, Jiangxi 330006, China Department of ...
Frontiers15d
Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma
Bioinformatics tools were employed to analyze gene expression patterns and signalling pathways. Results: The findings indicated that MVI-positive malignant cells activate multiple signalling pathways ...
The Daily News20d
Verastem Oncology Outlines 2025 Strategic Priorities and Milestones for Novel Pipeline Targeting RAS/MAPK Pathway-Driven Cancers
Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced its 2025 priorities and upcoming ...
Business Standard21d
Canada PR: 4 new permanent residency pathways to be introduced in 2025
Want to apply for Canada PR? The country is set to introduce four new permanent residency (PR) pathways in 2025, even as the government plans to reduce its PR targets from 485,000 to 465,000, ...
Health Affairs27d
Quality Pathway Implementation At The CMS Innovation Center
Last year, the CMS Innovation Center launched the Quality Pathway strategic initiative to strengthen the focus on quality in alternative payment models. Since it was created, the CMS Innovation ...
C&EN28d
Multiple Reaction Pathways for Oxygen Evolution as a Key Factor for the Catalytic Activity of Nickel–Iron (Oxy)Hydroxides
We quantitatively compared seven OER pathways applicable to both the adsorbate evolution mechanism (AEM) and the lattice-oxygen-mediated mechanism (LOM) families, elucidating how iron significantly ...