Although these were hotly debated issues at the time, it is now clear that a multitude of signal transduction pathways and numerous regulatory mechanisms have evolved to keep MYC expression under ...

13 To define the enrichment of MYC pathway genes and the other correlated pathways or functional program at the individual sample level, we made a modification to the GSEA algorithm called ...

IntroductionHepatocellular carcinoma (HCC) is one of the deadliest cancers globally, with increasing incidence and mortality rates. It arises from ...

This is a very powerful oncogenic pathway set off by MYC activation. We need to understand this complex cascade of events in detail to find out more effective ways to manage the disease." ...

“We are excited by the work of Dr. Pourdehnad and colleagues and believe these results are an important advance in understanding the role of myc pathway dysregulation in multiple ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.