but can also enter the cycle through pyruvate carboxylase. Because islets lack PEPCK activity, the pyvuate/malate or pyvuate/citrate cycling pathways shown could represent important pathways for ...

Moreover, the inactivation of pyruvate dehydrogenase (PDH ... carnitine palmitoyltransferase 1; MDH1, malate dehydrogenase; BPTES, bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl) ethyl sulfide. Over ...

The pyruvate formed is reduced by NADH in a reaction catalyzed ... L-aspartate and 2-oxoglutarate to yield oxaloacetate and L-glutamate. In the presence of malate dehydrogenase, oxaloacetate reacts ...

A Prescription Drug User Fee Act target date of May 27, 2025 has been assigned to the application. The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application ...

There are multiple types of magnesium, some of which may be better for treating certain symptoms and conditions than others. Examples include magnesium citrate and magnesium glycinate. They may ...

Hyperpolarized [1-13 C] pyruvate experiments revealed distinct metabolic profiles for the two cell types, highlighting the bioreactor’s ability to discern metabolic profiles among samples. Our results ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Metabolic requirements of dividing hepatocytes ...

1 M sodium malate) or ATP (from a 750 mM stock), protein, and lastly ThT (from a 150 µM stock). Wells in a 384-well plate were flushed with 100 µL water prior to setting up the reaction which were ...

Bone remodeling is a continuous cyclic process that maintains and regulates bone structure and strength. The disturbance of bone remodeling leads to a series of bone metabolic diseases. Recent studies ...

2023 Apr;29(3):862-872. doi:10.1111/odi.14116 Burnett CL, Bergfeld WF, Belsito DV, et al. Amended safety assessment of malic acid and sodium malate as used in cosmetics. Int J Toxicol.