Panel B describes the refined model of KRAS activation informed by the ... GEF guanine exchange factor, MEK mitogen-activated protein kinase kinase, MT mutant, Pi inorganic phosphate, P13K phospho ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...

Researchers have discovered how a particular protein affects the growth and spread of colon cancer in humans. The study not ...

Lutris Pharma, a clinical stage biopharmaceutical company focused on improving anti-cancer therapies by reducing cutaneous ...

and abnormal activation of cardiac fibrosis is linked to various cardiac disorders through numerous molecular pathways and proteins. In particular, the transforming growth factor (TGF)-β/Smad pathway, ...

However, the clinical efficacy of mitogen-activated protein kinase (MAPK) pathway inhibitors (MAPKi) for MAP2K1-mutant tumors is not well defined. We sought to characterize the genomic and clinical ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... Constitutive ALK activity in cancers results in the activation of several downstream pathways that are shared with other tyrosine ...

This “bi-kinase module” sensitises the NADPH oxidase to calcium and enables synergistic activation of this enzyme, which then produces more reactive oxygen species. One of the two calcium-dependent ...

retriever generates disease-specific transcriptional drug response signatures by merging transcriptional signatures over time, concentration, and cell-type. These signatures can then be matched to ...

We have developed a new strategy to measure the activation of kinases in small, single, mammalian cells. Rather than microscopic imaging, the method relies on the strengths of chemical separation ...

An enzyme that helps clear damaged mitochondria can act as a molecular switch and potentially prevent neurons from dying.