Safeguarding intestinal stem cells during aging through balanced signaling
A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a ...
News Medical on MSN18h
New insight into gut stem cell aging
A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular ...
Nature21d
Mitogen-Activated Protein Kinase Signaling Pathways and Inhibitors
Mitogen-Activated Protein Kinase (MAPK) signaling pathways play a crucial role in various cellular processes, including growth, differentiation, and response to stress. These pathways are ...
C&EN1h
FDA approves drug for neurofibromatosis
The US Food and Drug Administration has approved mirdametinib for the treatment of neurofibromatosis type 1 (NF1) in adults ...
News Medical on MSN8d
How olive oil bioactives regulate genes linked to insulin resistance
Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...
Lutris Pharma Secures $30 Million Financing To Advance The Development Of Biopharmaceutical To Improve Anti-Cancer Drug Effectiveness
In October 2024, Lutris successfully completed enrollment in the international phase 2 trial of LUT014 in patients with metastatic colorectal cancer (mCRC) treated with EGFRi therapy who develop ...
Nature21d
Cell Signaling Pathways in Cancer and Neuroprotection
through various signaling pathways, including the focal adhesion kinase (FAK) and mitogen-activated protein kinase (MAPK) pathways[3]. This finding underscores the importance of cell signaling in ...
Armed robbery in Revesby10d
Pfizer's BRAFTOVI Regimen Boosts Survival in Phase 3 Trial
Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...
EurekAlert!16d
Schematic illustration of Z526's effects on cancer-associated cachexia. (IMAGE)
In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...
gut.bmj21d
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...
Frontiers12d
Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses
Mitogen-activated protein kinases (MAPKs) in tomato plants have crucial ... regions of target genes and thereby suppressing or promoting gene expression. The MAPK pathways function as kinases and ...
Frontiers11d
Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts
Multiple signaling pathways, including Notch ... Extracellular regulated protein kinases; MAPK, Mitogen-activated protein kinase; MMP, Metalloproteinase; IL-6R, interleukine-6 receptor; IL-1βR, ...