To understand the full scope of this medication -- its effectiveness, risks, and who stands to benefit the most -- ...

Atherosclerotic cardiovascular disease is a major health concern worldwide and requires effective preventive measures. Lp(a) (lipoprotein [a]) has recently garnered attention as an independent risk ...

HDL is reduced. PCSK9, which reduces LDL receptor recycling, is increased. E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function, but its role in familial ...

Additionally, new anti-inflammatory and lipid-reducing drugs, including PCSK9 inhibitors and novel statin formulations, are playing a role in preventing the progression of intracranial atherosclerosis ...

For those patients there is a new group of medicine called PCSK9 inhibitors, which works to lower the cholesterol through a different mechanism. The two that are commercially available are Alirocumab ...

Novel lipid-lowering therapies such as proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) can dramatically lower low-density lipoprotein (LDL) and lipoprotein(a) levels, but are not ...

In this Review, we summarise common mechanisms driving acute and long-term side-effects and discuss monitoring strategies for radiotherapy survivors. We explore ways to mitigate toxic effects through ...

This review examines the influence of PCSK9 on the risk factors associated with ischemic stroke and explores its potential mechanisms, and briefly describes the application of PCSK9 inhibitors in ...

"These findings illuminate a critical mechanism that connects local synaptic activity to the broader gene expression changes necessary for learning and memory," said Mark Dell'Acqua, professor of ...

While the efficiency of PCSK9 mAbs, mipomersen and lomitapide has been demonstrated in FH patients, there has been no completed trial with new CETP inhibitors in FH, but one trial is underway ...

Today, Canada alongside other G7 RRM members (European Union, France, Germany, Italy, Japan, the United Kingdom, the United States) as well as G7 RRM Observer states (Australia, Netherlands, New ...