Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.

Microtubules are cylindrical polymers composed ... formation of the mitotic spindle that segregates chromosomes during cell division and intracellular trafficking. During cell adhesion, integrins ...

After chromosomes are aligned at equator, chromatids can finally segregate through depolymerization of attached microtubules and spindle pole movement. If this cycle is interrupted, the cell will not ...

Therefore, Elongator rewrites the tubulin code of growing microtubules, placing it at the core of cytoskeletal dynamics and polarization during asymmetric cell division. Elongator, an established tRNA ...

Protein filaments, like microtubules, and molecular motors ... which is responsible for correct cell division. Research conducted by a team at the University of California, Santa Barbara, using ...

The spindle assembly checkpoint (SAC), composed of BUB and MAD proteins, ensures that chromosomes are properly attached to the spindle microtubules. In fungi and animals, at the start of cell division ...

Microtubules are essential to cell division, and taxanes therefore stop cell division — a 'frozen mitosis'. In contrast to the taxanes, the vinca alkaloids destroy mitotic spindles. Cancer cells ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...

Light and electron microscopy have distinct limitations. Light microscopy makes it difficult to resolve smaller and smaller features, and electron microscopy resolves small structures, but samples ...