Potent in vivo gene editing in skeletal muscle of non-human primates by a novel, ultracompact CRISPR system delivered via a single AAV vector.

NanoCas, an ultracompact nuclease, enables efficient muscle editing in NHPs using a single AAV - advancing gene editing for hard-to-target tissues.

Buijsen is in the Department of Human Genetics, Leiden University ... to develop into a variety of tissue types, including skeletal muscle cells and organoids composed of heart or brain cells ...

Myosin II plays the most important role in cellular force generation. Myosin II molecules self-assemble into filaments with different structures depending on myosin II isoforms and other conditions ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

However, despite the efforts to deliver the optimal cell population to multiple muscles most efforts have failed. Here we describe a detailed optimized method of for the delivery of human skeletal ...

assisting scientists in exploring how the space environment impacts the muscle and skeletal development of vertebrates. This research is expected to bolster long-term human survival in space and ...

11, 2025 — Researchers have discovered a new mechanism that is used by a male sex hormone essential for muscle and bone ... 2024 — A new study of human skeletal remains from the wreck of ...